由蚊媒传播的疾病,如疟疾、登革热、流行性乙型脑炎、黄热病等已严重影响人类健康,但至今尚无有效的防治方法.沃尔巴克氏体是在自然界中广泛存在的、经母系遗传的共生菌,可诱导蚊群产生胞质不相容.迄今为止,胞质不相容的分子机制尚未明确,但“锁-钥匙”模型(lock and key model)、“移除-归还”模型(titration-restitution model)和“减速”模型(slow-motion model)可在一定程度上解释胞质不相容现象.胞质不相容产生的整个过程极为复杂,是多种因子共同作用的结果.该文就胞质不相容的模型及分子机制进行综述.
Advance in developing Wolbachia-induced cytoplasmic incompatibility models and its molecular mechanism
Mosquito-borne disease such as malaria、dengue fever,epidemic,encephalitis and yellow fever has a serious impact on human health,but so far there is no effective control methods.Wolbachia are widespread in nature and are maternally inherited endosymbiontic bacteria which can induce cytoplasmic incompatibility(CI).To date,the molecular mechanism of CI has not been elucidated,but the "lock-key",the"-titration-restitution" and the "slow-motion" models could explain the phenomenon to a certain extent.The process of inducing CI is extremely complex,including variety of factors.
NETL
NSTL
万方数据
维普
