弓形虫感染对宿主T细胞功能的影响
Influence of Toxoplasma gondii infection on T cell function of host
王燕娟 1曹建平 1熊彦红 1沈玉娟1
作者信息
- 1. 200025上海,中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心
- 折叠
摘要
刚地弓形虫病对人类健康和畜牧业的发展危害严重.宿主T细胞介导的细胞及体液免疫在抗弓形虫感染中发挥着重要的作用.大量研究表明弓形虫感染能够通过凋亡或衰竭等方式导致宿主T细胞数量减少、功能受损,是弓形虫逃避宿主免疫的重要表现.该文就弓形虫感染对宿主T细胞的影响做一综述.
Abstract
Toxoplasmosis has caused serious harm to human health and the development of animal husbandry.T cell mediated cellular and humoral immunity plays important roles in the process of anti-Toxoplasma gondii infection.However,lots of research suggested that as an important way to evade the host immune system,the infection of Toxoplasma gondii could trigger reduced quantity and impaired function of the host T cells through T cell apoptosis or exhaustion.This article reviews the impairment of host T cells during Toxoplasma gondii infection.
关键词
弓形虫/T细胞/凋亡Key words
Toxoplasma gondii/T cell/Apoptosis引用本文复制引用
基金项目
上海市卫生局青年科研项目(20124Y078)
国家自然科学基金(81202301)
国家卫生行业科研专项(201502021)
出版年
2015
NETL
NSTL
维普
万方数据