Research progress on the immune characteristics and application of exhausted CD4 + T cells
李旭阳 1吕家誉 2韩敬泉 1徐进志1
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作者信息
1. 哈尔滨医科大学附属第四医院胸外科，哈尔滨 150000
2. 哈尔滨市第五医院外一科，哈尔滨 150040
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摘要
耗竭T细胞(exhausted T cell，Tex)的特征是细胞表面抑制性标记物表达增加，T细胞转录特点随之发生变化，进而表现为进行性和层次性免疫功能丧失。CD4＋T细胞在慢性感染或肿瘤环境下，会对其他浸润免疫细胞产生影响，参与肿瘤的病理进展和转归。研究表明，CD4＋T细胞在肿瘤微环境中会发生耗竭现象，这种耗竭现象可能与肿瘤的临床治疗效果直接相关。文章主要综述肿瘤中CD4＋Tex免疫学特点及免疫学功能，以期为肿瘤治疗提供新的靶点。 Exhausted T cells (Tex) are characterized by increased expression of cell-surface inhibitory markers and concomitant changes in T-cell transcriptional profiles, leading to a progressive and hierarchical immune dysfunction. CD4+ T cells can affect other infiltrating immune cells in chronic infection or tumor environments, participating in the pathological progression and prognosis of tumors. Researches have shown that CD4+ T cells can also be exhausted in tumor microenvironment, which may be directly related to the clinical treatment effectiveness of tumors. This review mainly summarizes the immunological characteristics and functions of CD4+ Tex in tumors, with the aim of providing new targets for tumor treatment.
Abstract
Exhausted T cells (Tex) are characterized by increased expression of cell-surface inhibitory markers and concomitant changes in T-cell transcriptional profiles, leading to a progressive and hierarchical immune dysfunction. CD4+ T cells can affect other infiltrating immune cells in chronic infection or tumor environments, participating in the pathological progression and prognosis of tumors. Researches have shown that CD4+ T cells can also be exhausted in tumor microenvironment, which may be directly related to the clinical treatment effectiveness of tumors. This review mainly summarizes the immunological characteristics and functions of CD4+ Tex in tumors, with the aim of providing new targets for tumor treatment.
关键词
耗竭CD4/＋T细胞/肿瘤/程序性死亡受体-1/免疫检查点抑制剂
Key words
Exhausted CD4 + T cell/Tumor/Programmed cell death protein-1/Immune checkpoint blockade
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