外泌体是含有核酸、蛋白质、脂质、细胞因子、转录因子受体等生物活性分子的细胞外囊泡，几乎所有的细胞都可以分泌外泌体。外泌体在免疫应答、神经元之间的信号传导、生殖和发育等多方面发挥重要作用。近年来，关于外泌体在特应性皮炎(atopic dermatitis，AD)、银屑病、玫瑰痤疮等非感染性炎症性皮肤病方面的研究也取得了一定的进展。文章就外泌体在AD病情进展、诊断和临床治疗领域的研究结果进行综述，以期为AD临床诊断和治疗提供依据。 Exosomes are extracellular vesicles containing bioactive molecules such as nucleic acids, proteins, lipids, cytokines and transcription factor receptors. Almost all cells can secrete exosomes. Exosomes play important roles in immune response, signal transduction among neurons, reproduction, and development etc. In recent years, researches on exosomes in non infectious inflammatory skin diseases such as atopic dermatitis(AD), psoriasis, and rosacea have also made certain progress. This review summarrizes the research results of exosomes in the progression, diagnosis, and clinical treatment of AD, in order to provide a basis for the clinical diagnosis and treatment.
Abstract
Exosomes are extracellular vesicles containing bioactive molecules such as nucleic acids, proteins, lipids, cytokines and transcription factor receptors. Almost all cells can secrete exosomes. Exosomes play important roles in immune response, signal transduction among neurons, reproduction, and development etc. In recent years, researches on exosomes in non infectious inflammatory skin diseases such as atopic dermatitis(AD), psoriasis, and rosacea have also made certain progress. This review summarrizes the research results of exosomes in the progression, diagnosis, and clinical treatment of AD, in order to provide a basis for the clinical diagnosis and treatment.
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