Research progress of bacterial lysate in the treatment of airway allergic diseases
李欣 1吕芸 2张玥钰 2何健2
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作者信息
1. 甘肃中医药大学第一临床医学院，兰州 730000
2. 甘肃省人民医院耳鼻咽喉头颈外科，兰州 730030
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摘要
细菌溶解产物(bacterial lysates，BLs)是近年兴起的一种免疫调节剂，它可以通过调节体内的免疫系统从而增强机体的抗感染能力。BLs还可以通过改变辅助性T细胞(help T cell，Th)1/Th2平衡降低变态反应的发生率。以往关于BLs的研究主要集中在预防儿童和成人反复呼吸道感染中，近些年在变应性疾病中的应用逐渐增多。文章就BLs在变应性气道疾病中的作用机制及最新研究进展进行综述。 Bacterial lysate (BLs) are a newly rising immunomodulator in recent years, which can enhance the anti-infection ability of the body by regulating the immune system. BLs can also reduce the incidence of allergic reactions by altering helper T cell (Th)1/ Th2 balance. Previous studies on BLs mainly focused on the prevention of recurrent respiratory tract infections in children and adults. In recent years, the application of BLs in allergic diseases has gradually increased. This review summarizes the mechanism and the latest research progress of BLs in allergic airway diseases.
Abstract
Bacterial lysate (BLs) are a newly rising immunomodulator in recent years, which can enhance the anti-infection ability of the body by regulating the immune system. BLs can also reduce the incidence of allergic reactions by altering helper T cell (Th)1/ Th2 balance. Previous studies on BLs mainly focused on the prevention of recurrent respiratory tract infections in children and adults. In recent years, the application of BLs in allergic diseases has gradually increased. This review summarizes the mechanism and the latest research progress of BLs in allergic airway diseases.
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