Cytokines and fibroblast-like synoviocytes in rheumatoid arthritis
李山山 1王皓 1周海舟1
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作者信息
1. 哈尔滨医科大学第一附属医院检验科，哈尔滨 150001
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摘要
类风湿性关节炎(rheumatoid arthritis，RA)是一种伴有多个关节肿、痛、畸形的免疫性疾病，严重情况下会引起关节功能的严重障碍，现已证实成纤维样滑膜细胞(fibroblast-like synoviocytes，FLS)与RA有极强的关联性，RA-FLS在RA发病机制中起关键作用。RA-FLS可自行产生多种炎性细胞因子，也可被某些细胞因子或物质刺激而产生多种炎性细胞因子，这些炎性细胞因子可增加RA-FLS的侵袭性和增殖能力，并减少RA-FLS的凋亡，从而进一步加重关节炎。文章重点探讨了几种可对RA-FLS产生影响的细胞因子，以期为治疗RA提供新的思路。 Rheumatoid arthritis (RA) is an immune disease with multiple joint swelling, pain and deformity, which can cause severe impairment of joint function in severe cases. Fibroblast-like synoviocytes (FLS) have been shown to have a strong association with RA, and plays a key role in the pathogenesis of RA. RA-FLS can produce a variety of inflammatory cytokines on its own, and also can be stimulated by certain cytokines or substances to produce a variety of inflammatory cytokines. These inflammatory cytokines can increase the aggressiveness and proliferative ability of RA-FLS and reduce the apoptosis of RA-FLS, thereby further aggravating arthritis. This review focuses on several cytokines that can have an impact on RA-FLS, in order to provide new ideas for the treatment of RA.
Abstract
Rheumatoid arthritis (RA) is an immune disease with multiple joint swelling, pain and deformity, which can cause severe impairment of joint function in severe cases. Fibroblast-like synoviocytes (FLS) have been shown to have a strong association with RA, and plays a key role in the pathogenesis of RA. RA-FLS can produce a variety of inflammatory cytokines on its own, and also can be stimulated by certain cytokines or substances to produce a variety of inflammatory cytokines. These inflammatory cytokines can increase the aggressiveness and proliferative ability of RA-FLS and reduce the apoptosis of RA-FLS, thereby further aggravating arthritis. This review focuses on several cytokines that can have an impact on RA-FLS, in order to provide new ideas for the treatment of RA.
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