The role of NFIL3 in tumor progression and chemotherapy resistance
薛欣 1白富强 1薛阳1
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作者信息
1. 黑龙江省第三医院精神科，哈尔滨 150030
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摘要
核因子白细胞介素-3调节因子(nuclear factor interleukin-3-regulated factor，NFIL3)属于碱性亮氨酸拉链家族成员之一，在人体组织中广泛表达，参与多种生理功能，在人体免疫稳态中具有重要作用。研究发现NFIL3在多种类型的肿瘤组织中异常表达，参与肿瘤的发生和发展，并与肿瘤细胞的化疗耐药有关。文章就NFIL3在肿瘤进展和化疗耐药中的作用进行综述。 Nuclear factor interleukin-3 regulated factor(NFIL3) is a member of the alkaline leucine zipper family and is widely expressed in human tissues. It participates in various physiological functions and plays an important role in the immune homeostasis of the human body. Researches have found that NFIL3 is abnormally expressed in various types of tumor tissues, participating in the occurrence and development of tumors, and is related to the chemotherapy resistance of tumor cells. This review summarizes the role of NFIL3 in tumor progression and chemotherapy resistance.
Abstract
Nuclear factor interleukin-3 regulated factor(NFIL3) is a member of the alkaline leucine zipper family and is widely expressed in human tissues. It participates in various physiological functions and plays an important role in the immune homeostasis of the human body. Researches have found that NFIL3 is abnormally expressed in various types of tumor tissues, participating in the occurrence and development of tumors, and is related to the chemotherapy resistance of tumor cells. This review summarizes the role of NFIL3 in tumor progression and chemotherapy resistance.
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