Research progress of loop-mediated isothermal amplification technology in the diagnosis ofHelicobacter pylori infection
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幽门螺杆菌(Helicobacter pylori, Hp)与很多胃肠道疾病甚至是胃肠外疾病密切相关。目前幽门螺杆菌的常规检测技术包括快速尿素酶试验、病理组织学检查、血清抗体检测、粪便抗原检测、尿素呼气试验等，随着在临床应用中发现这些技术均存在不同程度的缺陷，因此需要探索新技术来弥补。恒温核酸扩增技术中的环介导等温扩增(loop-mediated isothermal amplification，LAMP)技术近年发展迅速，具有快速、特异、敏感、简便等特点，使该技术在核酸检测领域得到了广泛的应用。文章就Hp感染诊断及LAMP技术在诊断、毒力分型领域内的研究进展进行综述，期望为后续研究者们提供更多信息。 Helicobacter pylori (Hp) is closely related to many gastrointestinal diseases and even parenteral diseases. The detection technologies for Hp include rapid urease test, histopathological examination, serum antibody detection, stool antigen detection, urea breath test, etc. As found in clinical applications, these technologies have various degrees of defects. Therefore, new technologies need to be explored to compensate. Loop mediated isothermal amplification (LAMP), one of thermostatic nucleic acid amplification techniques, has developed rapidly in recent years. This review focuses on the research progress of HP infection diagnosis and LAMP in the diagnosis, virulence typing of Hp, we hoping to provide more information for subsequent researchers.
Helicobacter pylori (Hp) is closely related to many gastrointestinal diseases and even parenteral diseases. The detection technologies for Hp include rapid urease test, histopathological examination, serum antibody detection, stool antigen detection, urea breath test, etc. As found in clinical applications, these technologies have various degrees of defects. Therefore, new technologies need to be explored to compensate. Loop mediated isothermal amplification (LAMP), one of thermostatic nucleic acid amplification techniques, has developed rapidly in recent years. This review focuses on the research progress of HP infection diagnosis and LAMP in the diagnosis, virulence typing of Hp, we hoping to provide more information for subsequent researchers.
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