自身免疫性疾病(autoimmune diseases，AID)是机体自身耐受被打破后，发生自身免疫反应引起局部或全身器官、组织的病理性损伤所致的疾病。微小RNA(microRNA，miRNA)是一类长度在18到25个核苷酸之间的单链内源性非编码RNA，在多种疾病中发挥重要作用，具有潜在的诊断和治疗意义。大量研究发现miRNA在AID发病机制中发挥着重要调控作用，文章总结了miRNA在AID中的研究进展。 Autoimmune disease (AID) is a disease caused by pathological damage of local or systemic organs and tissues caused by autoimmune reaction after the body's self-tolerance is broken. MicroRNA(miRNA) is a kind of single-stranded endogenous non-coding RNA with a length of between 18 and 25 nucleotides, which plays an important role in many diseases and has potential diagnostic and therapeutic significance. A large number of studies have found that miRNA plays an important regulatory role in the pathogenesis of AID. This paper will review the research progress of miRNA in AID.
Abstract
Autoimmune disease (AID) is a disease caused by pathological damage of local or systemic organs and tissues caused by autoimmune reaction after the body's self-tolerance is broken. MicroRNA(miRNA) is a kind of single-stranded endogenous non-coding RNA with a length of between 18 and 25 nucleotides, which plays an important role in many diseases and has potential diagnostic and therapeutic significance. A large number of studies have found that miRNA plays an important regulatory role in the pathogenesis of AID. This paper will review the research progress of miRNA in AID.
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