Research progress of PI3K/Akt signaling pathway in the pathogenesis of lupus nephritis
程芷洛 1孟祥文 1贾晓益 1张敏2
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作者信息
1. 安徽中医药大学药学院，合肥 230012
2. 中国科技大学第一附属医院（安徽省立医院）风湿免疫科，合肥 230001
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摘要
狼疮肾炎(lupus nephritis, LN)是系统性红斑狼疮(systemic lupus erythematosus, SLE)中常见的并发症，其中10%～20%的LN患者会在确诊后5年内发展到终末期肾病，进而危及生命。磷脂酰肌醇3激酶(phosphatidylinositol 3 kinase, PI3K)/蛋白激酶B(protein kinase B, Akt)(简称PI3K/Akt信号通路)是细胞周期过程中重要的信号通路之一。近几年显示PI3K/Akt信号通路与LN的发生发展有关，文章总结了PI3K/Akt信号通路在LN中的机制研究和相关抑制剂，以期为LN的治疗靶点提供新的思路。 Lupus nephritis(LN) is a common complication of systemic lupus erythematosus(SLE), with 10%~20% of patients with LN developing the life-threatening end-stage renal disease within 5 years of diagnosis.Phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt)(PI3K/Akt signaling pathway) is one of the important signaling pathways during the cell cycle.In recent years, it has been shown that PI3K/Akt signaling pathway is associated with the development of LN.The mechanistic studies of the PI3K/Akt signaling pathway in LN and related inhibitors, with a view to providing new ideas for therapeutic targets in LN were summarized.
Abstract
Lupus nephritis(LN) is a common complication of systemic lupus erythematosus(SLE), with 10%~20% of patients with LN developing the life-threatening end-stage renal disease within 5 years of diagnosis.Phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt)(PI3K/Akt signaling pathway) is one of the important signaling pathways during the cell cycle.In recent years, it has been shown that PI3K/Akt signaling pathway is associated with the development of LN.The mechanistic studies of the PI3K/Akt signaling pathway in LN and related inhibitors, with a view to providing new ideas for therapeutic targets in LN were summarized.
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