Research progress on oral microbes and rheumatoid arthritis
荀逸萌 1王秦 1张泽锦 1范婷婷1
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作者信息
1. 上海市奉贤区中心医院 肾内风湿科，上海 201400
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摘要
类风湿关节炎(rheumatoid arthritis，RA)是目前致残率较高的一种疾病。口腔微生物作为人类第二大微生物组已发现与免疫系统有着密切关系。共生微生物在维持体内平衡和健康方面发挥着核心作用，不仅通过阻断微生物活动，而且通过专门机制增强人类免疫系统。有研究指出RA患者的口腔微生物群落与健康人相比存在显著失调，这种生态失调可通过RA的治疗而恢复，且恢复程度与患者对治疗的反应密切相关。明确口腔微生物在RA发生发展中的作用，能为其治疗提供新的方向。 Rheumatoid arthritis(RA) is currently a disease with a high disability rate. The oral microbiome, the second largest microbiome in humans, has been found to be closely related to the immune system. Symbiotic microorganisms play a core role in maintaining balance and health within the body, not only by blocking microbial activity, but also by enhancing the human immune system through specialized mechanisms.Studies have pointed out that the oral microflora of patients with rheumatoid arthritis has a significant imbalance compared with healthy people, and this dysbiosis can be recovered by the treatment of rheumatoid arthritis, and the degree of recovery is closely related to the patient's response to treatment. Clarifying the role of oral microorganisms in the occurrence and development of rheumatoid arthritis can provide a new direction for its treatment.
Abstract
Rheumatoid arthritis(RA) is currently a disease with a high disability rate. The oral microbiome, the second largest microbiome in humans, has been found to be closely related to the immune system. Symbiotic microorganisms play a core role in maintaining balance and health within the body, not only by blocking microbial activity, but also by enhancing the human immune system through specialized mechanisms.Studies have pointed out that the oral microflora of patients with rheumatoid arthritis has a significant imbalance compared with healthy people, and this dysbiosis can be recovered by the treatment of rheumatoid arthritis, and the degree of recovery is closely related to the patient's response to treatment. Clarifying the role of oral microorganisms in the occurrence and development of rheumatoid arthritis can provide a new direction for its treatment.
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