Research progress on the correlation between CD137-CD137L and type 1 diabetes
李世兰 1薛君力1
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作者信息
1. 长江大学附属荆州医院，荆州 434020
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摘要
1型糖尿病(type 1 diabetes mellitus, T1DM)是一种多因素免疫介导的与自身免疫密切相关的疾病，其发病机制尚不完全明确，近年来发现，T细胞及其细胞亚群的活化与T1DM发生密切相关，而CD137-CD137L信号通路是T细胞活化的重要协调分子。文章就CD137-CD137L共刺激通路的相互作用及在T1DM发生、发展及免疫治疗中的影响进行综述。 Type 1 diabetes (T1DM) is a multifactorial immune mediated disease closely related to autoimmunity, and its pathogenesis is not completely clear. In recent years, it has been found that the activation of T cells and their subsets is closely related to the occurrence of T1DM, and CD137-CD137L signaling pathway is an important co modulator of T cell activation. The interaction of CD137-CD137L costimulatory pathway and its influence on the occurrence, development and immunotherapy in T1DM were reviewed.
Abstract
Type 1 diabetes (T1DM) is a multifactorial immune mediated disease closely related to autoimmunity, and its pathogenesis is not completely clear. In recent years, it has been found that the activation of T cells and their subsets is closely related to the occurrence of T1DM, and CD137-CD137L signaling pathway is an important co modulator of T cell activation. The interaction of CD137-CD137L costimulatory pathway and its influence on the occurrence, development and immunotherapy in T1DM were reviewed.
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