The structure and function of FKBP4 and its research progress in autoimmune diseases
曾琳娜 1朱洪涛2
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作者信息
1. 新疆医科大学儿科学院，乌鲁木齐 830000
2. 新疆医科大学第一附属医院儿内三科，乌鲁木齐 830000
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摘要
FK506结合蛋白52(FK506 binding protein 52，FKBP4)是FK506结合蛋白家族的一员，该蛋白质家族广泛地存在于生物体的器官和组织中。FKBP4是热休克蛋白90(heat shock proteins90，HSP90)的重要辅助蛋白，协同HSP90一起调控类固醇激素受体(steroid hormone receptor，SHR)成熟，增强SHR与相应激素结合，并促进SHR在胞内的核转移过程等生物学活动。近期的研究表明，FKBP4在多个通路中广泛参与人类疾病的发生和发展，特别是自身免疫性疾病。文章简要总结了FKBP4的分子构架和生物学作用，及其在自身免疫性疾病中的当前研究，以期为此类疾病的新疗法提供一些见解。 FK506 Binding Protein 52(FKBP4) is a member of the FK506 Binding Protein family, which is ubiquitously expressed in organs and tissues of living organisms.FKBP4 serves as a crucial accessory protein for Heat Shock Protein 90 (HSP90), collaborating with HSP90 to regulate steroid hormone receptor (SHR) maturation, enhance SHR binding to its corresponding hormones, and facilitate SHR nuclear translocation and other biological activities within cells. Recent studies have revealed that FKBP4 is broadly involved in the onset and progression of various human diseases, particularly autoimmune disorders. This review briefly summarizes the molecular architecture and biological functions of FKBP4, as well as its current research status in autoimmune diseases, with the aim of providing insights into novel therapeutic strategies for such conditions.
Abstract
FK506 Binding Protein 52(FKBP4) is a member of the FK506 Binding Protein family, which is ubiquitously expressed in organs and tissues of living organisms.FKBP4 serves as a crucial accessory protein for Heat Shock Protein 90 (HSP90), collaborating with HSP90 to regulate steroid hormone receptor (SHR) maturation, enhance SHR binding to its corresponding hormones, and facilitate SHR nuclear translocation and other biological activities within cells. Recent studies have revealed that FKBP4 is broadly involved in the onset and progression of various human diseases, particularly autoimmune disorders. This review briefly summarizes the molecular architecture and biological functions of FKBP4, as well as its current research status in autoimmune diseases, with the aim of providing insights into novel therapeutic strategies for such conditions.
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