Research progress of gaseous signal molecule hydrogen sulfide
Background Hydrogen sulfide (H2S) has been regarded as a noxious gas for a long time,studies in recent years has shown that H2S acts as the new discovered endogenous gas signal molecule at present,which has important biological activity and take part in many physiological and pathological processes widely.Objective To discuss the relation between the physiological and pathological effect of gaseous signal molecules H2S and diseases,and provides a detailed description of the research processes of H2S.Content H2S not only has therapeutic effects on ischemic diseases of multisystem,but also has two phases influence on neuropathic and inflammatory pain.The mechanism of effects of H2S might be related to its actions of endogenous vascular smooth muscle ATP-sensitive potassium channel (KATP) channel openers and also antioxidant activity.Trend These new findings of H2S have important significance for exploring the effective treatment for related clinical diseases.Future work should be emphasized on the precise mechanism of H2S for the influene on pain.
Hydrogen sulfideGaseous signal moleculeMechanism of action
NETL
NSTL
万方数据
维普
