Relationship between the expression of human leukocyte antigen DR on monocytes and acute exacerbation of chronic ob-structive pulmonary disease
Objective To investigate the relationship between the expression of leukocyte antigen DR(HLA-DR)on mono-cytes and acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 37 patients with acute exacer-bation of COPD(AECOPD)who were admitted to Tianjin Nankai Hospital and healthy persons for physical examination were selected.According to their clinical symptoms and infection indicators,the patients were divided into three groups:a healthy control group(n=15),an acute group(n=22,before clinical treatment intervention)and a stable group(n=16,after clinical intervention).Their peripheral blood samples were collected,and the expression of HLA-DR on CD 14+monocytes was detected by flow cytometry.Their relationships with C-reactive protein(CRP),white blood cell count,neutrophil percentage,neutrophil count,CD3+T lymphocyte percentage,CD3+CD4+T lymphocyte percentage,CD3+CD8+T lymphocyte percentage and CD4+/CD8+were analyzed.Results Compared with the healthy control group,patients in the acute group showed remarkable decreases in the levels of HLA-DR on CD14+monocytes(P＜0.05).Compared with the acute group,the stable group presented significant increases in the expression of HLA-DR on CD 14+mono-cytes(P＜0.05),decreases in CRP levels(P＜0.05),white blood cell count,neutrophil percentage and neutrophil count(all P＜0.05),and increases in CD3+CD4+T cell percentage,and CD4+/CD8+(all P＜0.05).In contrast,no significant changes were found in the percentage of CD3+T lymphocytes and the percentage of CD3+CD8+T lymphocytes(all P＞0.05).Correlation analysis indicated that,the expression of HLA-DR on CD14+monocytes in the peripheral venous blood of the acute group was negatively correlated with CRP,but positively correlated with the percentage of CD3+CD4+T lymphocytes and CD4+/CD8+.Conclusions The expression of HLA-DR on CD14+monocytes in AECOPD patients is reduced,which can be used as an auxiliary indicator to evaluate the immune system.
Chronic obstructive pulmonary diseaseMonocyteHuman leukocyte antigen DRC-reactive protein
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