Research advances on long non-coding RNA regulation mechanisms and prospective treatment targets in acute lung injury/acute respiratory distress syndrome
Long non-coding RNA(lncRNA)is involved in the development of acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)by regulating inflammation,oxidative stress,and immune response pathways.By studying the expression changes and mechanisms of lncRNA in ALI/ARDS,this can help to better understand the occurrence and development process of diseases.The article collects research reports mainly from the past three years,providing a comprehensive review of the regulatory and molecular mechanisms of lncRNA in regulating gene expression in ALI/ARDS.It summarizes the involvement of lncRNA in regulating gene ex-pression at the epigenetic level,transcriptional level,post-transcriptional level,and its participation in mediating cell apoptosis,cell necroptosis,cell autophagy,nuclear factor-KB(NF-κB)light chain enhancer of activated B cells signaling pathway activation and mac-rophage activation.The aim is to review and predict the role of lncRNA in the occurrence and development of ALI/ARDS,explore the therapeutic potential of lncRNA,and provide more potential therapeutic targets for clinical applications.
Long non-coding RNAAcute lung injuryAcute respiratory distress syndrome
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