Research advances of sodium leak channel contributes to neuropathic pain
Neuropathic pain(NP)is a common chronic pain in clinical practice,with a character of high incidence and refrac-tory to treatment,which seriously affects the quality of patients'life.Its pathogenesis and therapeutic targets have always been the fo-cus and difficulty of medical research.Sodium leak channel non-selective protein(NALCN)is a kind of voltage-independent,non-selective,and non-inactivating cation channel,which plays an important role in the generation of NP.The review summarizes re-cent study achievements on the structure and function of NALCN and variations mechanism to the NALCN involving in NP,including central sensitization,peripheral sensitization,regulation of the pain-inducing effects of substance P(SP),and cyclic adenylic acid(cAMP)/protein kinase A(PKA)signaling pathway,in order to provide a new direction for neuropathic pain study and treatment.
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