Research progress on the mechanism of loss of consciousness induced by sevoflurane
Sevoflurane is a common general anesthetic that can be used for inhalation induction and anesthesia maintenance.Recent years have seen some research progress on the mechanism of unconsciousness caused by sevoflurane.Studies concerning micro-scopic molecular targets have confirmed that type A receptors for γ-aminobutyric acid(GABA)(GABAA),nicotinic acetylcholine(Ach)receptors,and hyperpolarization-activated cyclic nucleotid-gated(HCN)channels are potential targets for loss of consciousness induced by sevoflurane,but the detailed mechanisms remain to be explored.In terms of mesoscopic neural circuits,multiple nucleus and neural circuits related to sleep-awake are involved in the sevoflurane-induced loss of consciousness.In addition,macroscopic non-invasive brain imaging techniques have revealed changes in consciousness-related neural oscillations,functional connectivity,and network topol-ogy under sevoflurane anesthesia.This review introduces the mechanism of unconsciousness induced by sevoflurane from multiple as-pects,which provides substantial evidence for monitoring clinical consciousness and lays a foundation for realizing precision anesthesia.
SevofluraneLoss of consciousnessMolecular targetNeural circuitsFunctional connectivityNeural oscillation
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