Research progress on non-coding RNA and related receptors regulating myeloid-derived suppressor cells in sepsis
Myeloid-derived suppressor cell(MDSC)are capable of limiting hyper-inflammation during the early stages of sep-sis,but exacerbate immunosuppression in the late stages of sepsis.This paper mainly reviews that,during the development of sepsis,MDSC are regulated by non-coding RNAs such as microRNA(miRNA)-21,miRNA-181b,miRNA-375,miRNA-150 and Hotairm1,as well as receptors such as interleukin-1 receptor(IL-1R),Toll-like receptor(TLR),tumor necrosis factor receptors(TNFR),programmed cell death receptor-1(PD-1),G protein-coupled bile acid receptor(TGR5),liver X receptor(LXR),and C-C motif chemokine receptor 2(CCR2),thereby exerting immune-suppressing effect.These findings provide certain theoretical evidence for searching the therapeutic targets for sepsis.
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