摘要
髓源性抑制细胞(MDSC)在脓毒症早期能够限制过度炎症反应,但在脓毒症晚期加剧免疫抑制.文章主要综述了MDSC在脓毒症发展过程中受微 RNA(miRNA)-21、miRNA-181b、miRNA-375、miRNA-150、Hotairm 1等非编码 RNA(ncRNA)及白细胞介素-1受体(IL-1R)、Toll样受体(TLR)、肿瘤坏死因子受体(TNFR)、程序性细胞死亡受体-1(PD-1)、G蛋白耦联胆汁酸受体5(TGR5)、肝脏X受体(LXR)和CC趋化因子受体2(CCR2)等受体调控,从而发挥免疫抑制作用,为寻找治疗脓毒症的靶标提供一定的理论依据.
Abstract
Myeloid-derived suppressor cell(MDSC)are capable of limiting hyper-inflammation during the early stages of sep-sis,but exacerbate immunosuppression in the late stages of sepsis.This paper mainly reviews that,during the development of sepsis,MDSC are regulated by non-coding RNAs such as microRNA(miRNA)-21,miRNA-181b,miRNA-375,miRNA-150 and Hotairm1,as well as receptors such as interleukin-1 receptor(IL-1R),Toll-like receptor(TLR),tumor necrosis factor receptors(TNFR),programmed cell death receptor-1(PD-1),G protein-coupled bile acid receptor(TGR5),liver X receptor(LXR),and C-C motif chemokine receptor 2(CCR2),thereby exerting immune-suppressing effect.These findings provide certain theoretical evidence for searching the therapeutic targets for sepsis.
基金项目
上海市自然科学基金(21ZR1460400)
上海市中医药三年行动计划(ZY2021-2023-0203-04)
NETL
NSTL
万方数据