神经系统在恶性肿瘤发生发展中的作用及机制
Roles and mechanisms of the nervous system in the occurrence and development of malignant tumors
陈金燕 1解康杰 2俞卫锋1
作者信息
- 1. 温州医科大学研究生培养基地(浙江省肿瘤医院),杭州 310022
- 2. 浙江省肿瘤医院麻醉科,杭州 310022
- 折叠
摘要
神经系统在恶性肿瘤中扮演不可或缺的角色.同时,恶性肿瘤也影响神经系统的结构和功能.肿瘤通过激活神经的发育和再生以促进其生长和存活.反过来,周围神经为肿瘤环境中的癌细胞和基质细胞提供营养,促进各系统恶性肿瘤的发生、发展.文章总结了恶性肿瘤与神经的相互作用及其机制,并介绍了针对神经-肿瘤相互作用下肿瘤的治疗方法及其研究进展,以期对未来深入研究神经与肿瘤之间的相互作用提供参考.
Abstract
The nervous system plays an indispensable role in malignant tumor formation and development.In the meantime,malig-nant tumors also affect the structure and function of the nervous system.Tumors promote their growth and survival by activating the pro-cess of nerve development and regeneration.In turn,peripheral nerves provide nutrients for cancer cells and stromal cells in the tumor micro-environment,promoting the occurrence and progression of malignant tumors in various systems.This review summarizes the interac-tion between malignant tumors and the nervous system and explains their mechanisms.It also introduces the treatment methods and research advances in terms of tumors'interaction with the nervous system,aiming to provide a reference for future in-depth research on the interaction between the nervous system and tumors.
关键词
神经系统/肿瘤/肿瘤微环境/癌症神经科学Key words
Nervous system/Neoplasm/Tumor microenvironment/Cancer neuroscience引用本文复制引用
基金项目
浙江省卫生健康科技计划青年创新人才项目(2022RC015)
浙江省中医药科技计划(2023ZL302)
出版年
2024
NETL
NSTL
万方数据