外泌体微RNA在肺部疾病中的研究进展
Research advances of exosome microRNA in pulmonary diseases
陈薇 1吴晓炀 1武雅 1余剑波 2宫丽荣2
作者信息
- 1. 天津医科大学附属南开医院麻醉与重症医学科,天津 300100
- 2. 天津医科大学附属南开医院麻醉与重症医学科,天津 300100;天津市中西医结合急腹症研究所,天津 300100;天津市急腹症器官损伤与中西医修复重点实验室,天津 300100
- 折叠
摘要
外泌体作为一种纳米级载体,是细胞外囊泡最主要的类型之一.微RNA(microRNA,miRNA)是在真核生物中发现的一类具有内源性调控功能的非编码RNA.外泌体miRNA在肺部疾病中具有广泛的应用前景.文章综述了外泌体miRNA可通过多种物质/信号传递调节肺部疾病,如急性肺损伤、肺癌、慢性阻塞性肺疾病、新型冠状病毒感染,着重介绍外泌体miRNA关于上述肺部疾病的诊断、治疗的研究进展.随着外泌体miRNA在肺部疾病研究的不断深入,未来可能为肺部疾病的诊断和治疗提供更多的新思路和新方法.
Abstract
Exosomes,as a nano-scale carrier,are one of the most important types of extracellular vesicles.MicroRNA(miRNA)are a class of non-coding RNAs with endogenous regulatory functions found in eukaryotic organisms.Exosome-derived miRNA has broad application prospects in pulmonary diseases.This article reviews that exocrine miRNA can regulate lung diseases through a vari-ety of substances/signal transduction,such as acute lung injury,lung cancer,chronic obstructive pulmonary disease,and COVID-19.This review focuses on the research advances of exosome miRNA in the diagnosis and treatment of the above-mentioned lung diseases.With the deepening of the research on exosome miRNA in lung diseases,more new ideas and methods may be provided for the diagno-sis and treatment of lung diseases in the future.
关键词
外泌体/微RNA/肺部疾病Key words
Exosomes/MicroRNA/Lung diseases引用本文复制引用
出版年
2024
NETL
NSTL
万方数据