Research progress on orexin system in learning and memory function impaired by sleep deprivation
Sleep deprivation(SD)refers to the sleep deprivation caused by the outside world or its own reasons.SD has pro-found impacts on both physical and mental health.There is a growing concern about its impact on cognitive function,but its related mechanisms are still unclear and there is a lack of safe and effective treatment methods.Orexin is a neuropeptide produced by the hypo-thalamus and mainly plays a role in the central system.In recent years,it has been found to exert a wide range of effects on the regula-tion of food intake,sleep cycles,and cognition.This review explores the possible mechanisms of orexin in sleep and learning memory,providing a new perspective for the mechanism exploration and clinical treatment of SD-related cognitive dysfunction.
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