Research progress on aldehyde dehydrogenase 2 in pain regulation
Pain is an unpleasant feeling and emotional experience related to actual or potential tissue damage.Active alde-hyde,as a trigger and product of oxidative stress,is one of the important factors to mediate the occurrence and development of pain.Re-searches have found that aldehyde dehydrogenase 2(ALDH2),a rate-limiting enzyme of ethanol metabolism,plays a key role in clear-ing active aldehyde in body.It is a promising target for the treatment and regulation of pain.In this review,we focus on the diverse path-ways in which the reactive aldehydes induce or exacerbate pain symptoms,and further discuss the underlying mechanisms by which ALDH2 regulates the occurrence of pain,in order to provide a possible pathway for individualized pain treatment in clinical practice.
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