摘要
急性肾损伤(AKI)是围手术期常见的并发症,与死亡风险的增加、其他术后并发症的发生、住院时间的延长和潜在慢性肾病的进展密切相关.目前大多研究均展现出右美托咪定(Dex)对肾功能的保护作用.非心脏手术术后AKI的发生机制复杂,Dex通过稳定肾血流动力学、利尿、抗炎等机制以降低术后AKI的患病率.文章主要阐述Dex对肾功能的保护机制、静脉输注Dex策略以及静脉输注Dex的相关研究进展,以期为临床提供参考.
Abstract
Acute kidney injury(AKI)is a common perioperative complication that is strongly associated with an increased risk of death,other postoperative complications,prolonged length of hospitalization stay,and the progression of potential chronic kidney dis-ease.At present,most studies have shown the protective effect of dexmedetomidine(Dex)on renal function.The pathogenesis of AKI af-ter non-cardiac surgery is complex.Dex can reduce the prevalence of AKI through stabilizing renal hemodynamics,diuresis,anti-inflammation and other mechanisms.This article mainly describes the protective mechanism of Dex on renal function,the strate-gies of intravenous Dex infusion,and the related research progress on intravenous Dex infusion,in order to provide clinical reference.
NETL
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