艾司氯胺酮在围手术期的应用研究进展
Application and research advances of esketamine in perioperative period
刘震 1黄春霞 1李锐1
作者信息
- 1. 安徽医科大学第二附属医院麻醉与围术期医学科,合肥 230601
- 折叠
摘要
艾司氯胺酮是消旋氯胺酮中更强效和安全的右旋体,作用于N-甲基-D-天冬氨酸(NMDA)受体和非NMDA受体通路,能产生良好的镇静、镇痛效果,具有代谢快和副作用少等优点,在围手术期应用广泛.文章重点阐述艾司氯胺酮的作用机制、对围手术期生理功能的影响以及其在去阿片化麻醉、多模式镇痛、抗抑郁和改善睡眠等方面的应用进展,为其更合理和安全地应用于临床提供参考.艾司氯胺酮可能有助于促进患者术后恢复并提高生活质量.
Abstract
Esketamine is a potent and safe dextrorotary form of racemic ketamine.It acts on NMDA receptors and non-NMDA receptor pathways and can produce good sedative and analgesic effects.Esketamine has the advantages of rapid metabolism and few side effects so it is widely used in the perioperative period.This review focuses on the mechanism of action of esketamine,its impact on perioperative physiological functions,and the progress of its application in de-opioid anesthesia,multimodal analgesia,antidepressant and sleep improvement.It provides a reference for more reasonable and safe clinical application of esketamine.Esketamine may help facilitate postoperative recovery and improve patients'quality of life.
关键词
艾司氯胺酮/围手术期/麻醉/镇痛Key words
Esketamine/Perioperative period/Anesthesia/Analgesia引用本文复制引用
基金项目
安徽省转化医学研究院科研基金(2022zhyx-C53)
湖北陈孝平科技发展基金会临床研究专项基金(CX-PJJH12000005-07-119)
出版年
2024
NETL
NSTL
万方数据