前扣带皮质调控疼痛及痛行为的神经环路机制
The neural circuit mechanism of the anterior cingulate cortex in regulating pain
徐云 1王迎娣 2刘青 3戴思成 3周楠 3陆娟1
作者信息
- 1. 上海市保健医疗中心麻醉科,上海 200001
- 2. 苏州大学附属无锡九院麻醉科,无锡 214062
- 3. 上海市保健医疗中心门诊护理科,上海 200001
- 折叠
摘要
疼痛是一种与实际或潜在组织损伤相关的不愉快的感觉和情感体验,或与此相似的经历.疼痛的长期存在不仅给患者带来极大的生理性伤害,还对患者造成难以治愈的神经精神困扰,如焦虑、抑郁等.疼痛感知的发生和传导机制尚未明确.文章立足于大脑疼痛相关的多维体验中心——前扣带皮质(ACC),论述和总结了目前临床上不同疼痛状态或与疼痛相关的情绪障碍下ACC的功能成像变化,以及前临床研究中ACC及其相关神经环路在调节疼痛及相关负性情绪共病方面的最新研究进展和成果,以对未来的疼痛相关神经环路研究提供更深层次的理解.
Abstract
Pain is an unpleasant sensory and emotional experience associated with,or similar to,actual or potential tissue dam-age.The long-term existence of pain not only brings great physiological harm to patients but also causes difficult-to-treat neuropsychiat-ric distress,such as anxiety and depression.The occurrence and transmission mechanism of pain perception are not yet clear.Here,we focus on the anterior cingulate cortex(ACC),the pain-related multi-dimensional experience center of the brain,to discuss and summa-rize the current clinical pain status and pain-related functional imaging changes of the ACC during mood disorders,as well as the latest research advances of the ACC and its related neural circuits in pain regulation and related negative emotional comorbidities in preclini-cal studies,to provide novel insights and deeper understanding into future pain-related neural circuits research.
关键词
前扣带皮质/慢性疼痛/焦虑/抑郁Key words
Anterior cingulate cortex/Chronic pain/Anxiety/Depression引用本文复制引用
基金项目
无锡市卫生健康委科研项目计划(Q202341)
出版年
2024
NETL
NSTL
万方数据