Research advances in the role of homologous phosphatase tensin induced kinase 1/Parkinson's protein mediated mitochon-drial autophagy in perioperative neurocognitive disorders
Perioperative neurocognitive disorders(PND),as a common type of neurological complication after anesthesia and surgery,seriously affect the postoperative outcomes of patients.Although the exact pathogenic mechanism of PND is currently unclear,recent studies have shown that the homologous phosphatase tensin induced kinase 1(PINK1)/Parkinson's protein(Parkin)mitochondri-al autophagy pathway has a potentially important regulatory role in the occurrence and development of PND caused by different anes-thetic drugs and methods.Therefore,this review introduces the PINK1/Parkin mitochondrial autophagy pathway and lists common anes-thetic drugs and methods that participate in regulating the PINK1/Parkin mitochondrial autophagy pathway through oxidative stress and/or neuroinflammation.It can provide new therapeutic targets and directions for the prevention and treatment of PND.
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