PINK1/Parkin介导的线粒体自噬在围手术期神经认知障碍中的作用研究进展
Research advances in the role of homologous phosphatase tensin induced kinase 1/Parkinson's protein mediated mitochon-drial autophagy in perioperative neurocognitive disorders
赵旦 1侯朵 2倪娟娟 1冒晓清 1书伦 2袁维秀 2徐龙河 3高明龙 2冯龙2
作者信息
- 1. 山西医科大学麻醉学院,太原 030001
- 2. 解放军总医院海南医院麻醉科,三亚 572000
- 3. 解放军总医院第三医学中心麻醉科,北京 100039
- 折叠
摘要
围手术期神经认知障碍(PND)作为一类常见的麻醉手术后神经系统并发症,严重影响患者术后转归.PND的确切致病机制目前尚不清楚,但最近研究显示,同源性磷酸酶张力蛋白诱导激酶1(PINK1)/帕金森蛋白(Parkin)线粒体自噬通路在不同麻醉药物和方法所致PND的发生、发展过程中具有潜在重要调控作用.文章介绍了 PINK1/Parkin线粒体自噬通路,列举了常见的麻醉药物和麻醉方法通过氧化应激和(或)神经炎症等途径参与调控PINK1/Parkin线粒体自噬通路,为PND的防治提供新的治疗靶点和思路.
Abstract
Perioperative neurocognitive disorders(PND),as a common type of neurological complication after anesthesia and surgery,seriously affect the postoperative outcomes of patients.Although the exact pathogenic mechanism of PND is currently unclear,recent studies have shown that the homologous phosphatase tensin induced kinase 1(PINK1)/Parkinson's protein(Parkin)mitochondri-al autophagy pathway has a potentially important regulatory role in the occurrence and development of PND caused by different anes-thetic drugs and methods.Therefore,this review introduces the PINK1/Parkin mitochondrial autophagy pathway and lists common anes-thetic drugs and methods that participate in regulating the PINK1/Parkin mitochondrial autophagy pathway through oxidative stress and/or neuroinflammation.It can provide new therapeutic targets and directions for the prevention and treatment of PND.
关键词
同源性磷酸酶张力蛋白诱导激酶1/帕金森蛋白/线粒体自噬/围手术期神经认知障碍/麻醉/麻醉药Key words
Homologous phosphatase tensin induced kinase 1/Parkinson's protein/Mitophagy/Perioperative neurocog-nitive disorders/Anesthesia/Anesthetic引用本文复制引用
基金项目
海南省自然科学基金面上项目(821MS112)
海南省自然科学基金面上项目(822MS198)
出版年
2024
NETL
NSTL
万方数据