三甲胺N-氧化物在认知障碍相关疾病中的研究进展
Research advances of trimethylamine N-oxide in cognitive impairment diseases
郭虹妍 1李乔 1赵玉晶 1李青 1李岩松 1王强1
作者信息
- 1. 西安交通大学第一附属医院麻醉科,西安 710061
- 折叠
摘要
三甲胺N-氧化物(TMAO)是一种常见的肠道菌群代谢产物,血浆TMAO水平与中枢认知障碍相关疾病有着较强的相关性,在阿尔茨海默病、帕金森病、老年相关性痴呆、围手术期神经认知障碍等多种疾病中均有升高的趋势,可以作为认知障碍相关疾病的预测因子.文章综述了既往关于TMAO与认知障碍相关疾病的临床研究与基础研究,概括了TMAO在其中发挥作用的可能机制,以期为认知障碍相关疾病的防治提供新的思路与参考.
Abstract
Trimethylamine N-oxide(TMAO)is a metabolite commonly produced by intestinal flora.Elevated levels of TMAO in plasma have been strongly associated with central cognitive impairment-related diseases such as Alzheimer's disease,Parkinson's disease,age-related cognitive decline,and perioperative neurocognitive disorders.TMAO has shown potential as a predictive marker for cognitive impairment-related diseases.This review aims to summarize previous clinical and basic research on TMAO and its connec-tion to cognitive impairment-related diseases.Additionally,it will explore the potential mechanisms through which TMAO influences these diseases,offering new insights and references for the prevention and treatment of cognitive impairment-related diseases.
关键词
三甲胺N-氧化物/认知障碍Key words
Trimethylamine N-oxide/Cognitive impairment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据