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短链脂肪酸对认知功能障碍影响的研究进展

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认知功能障碍是由各种因素造成的记忆、计算、学习等能力不同程度的下降,其涵盖范围从各种因素引起的认知功能障碍到痴呆.短链脂肪酸(SCFA)在微生物-脑-肠轴(MGBA)的相互作用中扮演重要角色,其可通过炎症、免疫、内分泌等通路介导脑-肠之间的相互联系.文章着重介绍SCFA在不同病理条件下与认知功能障碍相关性的临床研究,以及通过构建动物模型,直接(补充SCFA)或间接(改变饮食和肠道菌群组成)改变机体内SCFA的含量,探讨SCFA影响认知功能障碍相关机制的基础研究.文章通过对SCFA在认知功能障碍患者及动物模型中的相关研究进行综述,以期为未来益生菌及SCFA的临床转化相关研究提供参考.
Research advances on the impact of short-chain fatty acid on cognitive dysfunction
Cognitive dysfunction encompasses a spectrum of diminished abilities,including memory,computation,and learn-ing,resulting from diverse factors,ranging from cognitive impairments to dementia.Short-chain fatty acids(SCFA)play a pivotal role in the intricate interplay of the microbiota-brain-gut axis(MGBA),mediating the bidirectional communication between the brain and the gut through pathways of inflammation,immunity,and endocrine signaling.This manuscript mainly introduces the clinical researches that investigate the association between SCFA and cognitive dysfunction under various pathological conditions.Additionally,this re-view also introduces basic researches that investigate the mechanisms underlying the impact of SCFA on cognitive impairment by set-ting up animal models.The investigation alters the SCFA levels through direct supplementation of SCFA or indirect modulation of SC-FA levels within the organism through interventions such as dietary modifications and alterations in gut microbiota composition.The aim of this review is to provide a comprehensive summary of researches on the correlation of SCFA with cognitive dysfunction in both patients and rodent models to contribute insights for future clinical translational studies in the realm of probiotics and SCFA.

Cognitive dysfunctionShort-chain fatty acidIntestinal floraBrain-gut axis

刘行、王海云

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天津医科大学三中心临床学院,南开大学附属第三中心医院,天津市重症疾病体外生命支持重点实验室,天津市人工细胞工程技术研究中心,天津市肝胆疾病研究所,天津 300170

认知功能障碍 短链脂肪酸 肠道菌群 脑-肠轴

国家自然科学基金面上项目国家自然科学基金面上项目天津市自然科学基金面上项目天津市卫生健康委员会科技基金面上项目天津市医学重点学科(专科)建设项目天津市医学重点学科专项

820712208237120520JCYBJC01290MS20013TJYXZDXK-072CTJWJ2023XK019

2024

10.3760/cma.j.cn321761-20240207-01103

国际麻醉学与复苏杂志
中华医学会,徐州医学院

国际麻醉学与复苏杂志

CSTPCD
影响因子：0.909
ISSN：1673-4378
年,卷(期)：2024.45(8)