Research advances in post-stroke brain-heart interaction and organ protection
Stroke-induced cardiovascular dysregulation holds significant scientific and clinical relevance in elucidating the complexity of brain-heart interactions.Extensive clinical data substantiate that stroke can precipitate a spectrum of cardiovascular dys-functions,including,but not limited to,arrhythmias,impaired myocardial pump function,which are closely associated with increased mortality rates.The term"brain-heart axis"refers to the intricate bidirectional functional network interconnecting the heart and the brain.This review aims to synthesize recent findings from in vitro studies to delineate the complex pathophysiological mechanisms of brain-heart interaction after cerebral ischemic stroke,including hypothalamic-pituitary-adrenal(HPA)axis,enhanced sympathetic and parasympathetic activity,immunoinflammatory responses,and intestinal flora dysregulation,and to propose protective strategies for cardio-cerebral organs following stroke,so as to improve the survival of the patients.
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