Research progress on the mechanism of brain neuron death after cardiac arrest resuscitation
Post-cardiac arrest patients often experience various degrees of neurological dysfunction,with widespread death of brain neurons being a major cause of post-resuscitation brain injury.Traditional studies suggest that necrosis and apoptosis are the pri-mary forms of neuronal death after resuscitation.However,with advances in research on cell death mechanisms,it has been discovered that neurons may also undergo ferroptosis,pyroptosis,necroptosis,PANoptosis,and autophagy following resuscitation.This article re-views the possible neuronal death pathways after cardiac arrest and resuscitation,emphasizing that a comprehensive understanding of these pathways can facilitate interventions targeting different steps of the cascade reaction,thereby delaying neuronal death or rescuing dysfunctional neurons.This is of great significance for reducing the incidence of neurological sequelae.Furthermore,the article discuss-es the potential application of various inhibitors targeting neuronal death mechanisms,in order to provide more theoretical reference for brain protection after resuscitation.
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