Research progress on the application of mitochondrial quality control in the occurrence,development and treatment of isch-emia reperfusion injury
Ischemia reperfusion injury(IRI)is a complex pathological process caused by factors such as surgical trauma and stress,which can lead to severe multi-organ dysfunction and even be life-threatening.Mitochondrial quality control(MQC)plays a key role in the occurrence and progression of IRI by regulating mitochondrial morphology and function as an adaptive response.MQC in-volves processes such as mitochondrial fission,fusion,and autophagy,and its dynamic balance is essential for maintaining cellular ho-meostasis.This article reviews the mechanisms by which MQC functions in IRI and analyzes potential therapeutic strategies aimed at improving IRI by regulating MQC,providing new insights and foundations for the research and treatment of IRI.
Ischemia reperfusion injuryMitochondrial quality controlMitochondrial dynamicsMitochondrial autopha-gyMitochondria-dependent cell death
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