Research progress on the treatment of acute lung injury by exogenous mitochondrial transplantation
The incidence and mortality rates of acute lung injury(ALI)remain high,and mitochondrial dysfunction plays a cru-cial role in the occurrence and progression of ALI.Studies have shown that mitochondrial transplantation derived from mesenchymal stem cells(MSC)or their exosomes has therapeutic effect on ALI.However,the sources of exogenous mitochondria and the mechanisms by which they treat ALI still require further investigation.This article reviews previous studies on the sources of exogenous mitochon-dria,the mechanisms of mitochondrial internalization,and the therapeutic effects of mitochondrial transplantation in ALI.It summariz-es the feasibility,potential value,and challenges of exogenous mitochondrial transplantation for treating ALI,in an effort to provide new ideas and reference for the prevention and treatment of acute lung injury.
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