国际麻醉学与复苏杂志2024,Vol.45Issue(12) :1326-1329.DOI:10.3760/cma.j.cn321761-20240408-01178

细胞治疗在脓毒症救治中的前景

Application of cell therapy in the treatment of sepsis

华叶婧 毛佳丽 方向明
国际麻醉学与复苏杂志2024,Vol.45Issue(12) :1326-1329.DOI:10.3760/cma.j.cn321761-20240408-01178

细胞治疗在脓毒症救治中的前景

Application of cell therapy in the treatment of sepsis

华叶婧 1毛佳丽 1方向明1
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作者信息

  • 1. 浙江大学医学院附属第一医院麻醉科,杭州 310003
  • 折叠

摘要

脓毒症是严重威胁人类健康的全球卫生问题,具有较高的发病率和病死率.经过几十年的研究,脓毒症仍然没有特定、有效的救治药物.近年来,基础和临床研究报道提示细胞疗法在脓毒症救治中存在一定的转化前景.文章综述了不同类型的免疫细胞及其功能特点,重点分析了当前细胞疗法在治疗脓毒症中的应用现状与发展趋势,详细介绍各类免疫细胞在脓毒症中的作用机制,并探讨细胞疗法在脓毒症治疗中的潜力和临床研究进展,以期提供有助于改善脓毒症患者预后的前沿信息,并为未来的研究方向和治疗策略提供科学依据.

Abstract

Sepsis is a global health issue that poses a serious threat to human health,with high incidence and mortality rates.Despite decades of research,there is still no specific and effective therapeutic agent for sepsis.In recent years,basic and clinical re-search has suggested that cell therapy holds certain translational potential in the treatment of sepsis.This article reviews the different types of immune cells and their functional characteristics,with a focus on analyzing the current status and development trends of cell therapy in sepsis treatment.It provides a detailed introduction to the mechanisms of various immune cells in sepsis,and explores the potential and clinical progress of cell therapies,including cell expansion and gene editing technologies in sepsis treatment.This article aims to provide cutting-edge information to improve the prognosis of sepsis patients and offer a scientific basis for future research direc-tions and therapeutic strategies.

关键词

细胞治疗/脓毒症/线粒体

Key words

Cell therapy/Sepsis/Mitochondria

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出版年

2024
国际麻醉学与复苏杂志
中华医学会,徐州医学院

国际麻醉学与复苏杂志

CSTPCD
影响因子:0.909
ISSN:1673-4378
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