The intestinal flora and its metabolites influence human metabolism in various ways and play a significant role in ischemia reperfusion injury(IRI).Numerous studies have shown that IRI is associated with multiple forms of programmed cell death(PCD).In this paper,we will summarize the effects of gut flora and its metabolites on IRI-related PCD,describe the mechanisms of dif-ferent types of PCD,and review current studies that confirm the impact of gut flora and its metabolites on PCD at both cellular and ani-mal levels.This review aims to pave the way for further research on IRI-related PCD in the future.
关键词
肠道微生物/程序性细胞死亡/缺血再灌注损伤
Key words
Gut microbiota/Programmed cell death/Ischemia reperfusion injury