脂蛋白相关磷脂酶A2与脑小血管病患者的认知损害
Lipoprotein-associated phospholipase A2 and cognitive impairment in patients with cerebral small vessel disease
姚赛 1闫聪聪 2白雪 1靳玮3
作者信息
- 1. 河北北方学院研究生院,张家口 075000
- 2. 华北理工大学研究生院,唐山 063210
- 3. 河北省人民医院神经内科,石家庄 050051
- 折叠
摘要
近年来,脑小血管病(cerebral small vessel disease,CSVD)的发病率随着人口老龄化而不断增高,且其导致的认知损害给患者及家庭带来巨大负担.作为一种新型的炎性标志物,脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)通过调节循环血管损伤和神经炎症直接参与CSVD患者认知损害的发病机制,有望成为CSVD的预测指标和治疗靶点.
Abstract
In recent years,the incidence of cerebral small vessel disease(CSVD)has been increasing with the aging of the population,and the cognitive impairment caused by it has brought huge burden to patients and their families.As a novel inflammatory biomarker,lipoprotein-associated phospholipase A2(Lp-PLA2)directly participates in the pathogenesis of cognitive impairment in patients with CSVD by regulating circulatory vascular injury and neuroinflammation,and is expected to become a predictive indicator and therapeutic target for CSVD.
关键词
脑小血管疾病/认知障碍/1-烷基-2-乙酰甘油磷酸胆碱酯酶/磷脂酶A2Key words
Cerebral small vessel diseases/Cognition disorders/1-Alkyl-2-acetylglycerophospho-choline esterase/Phospholipases A2引用本文复制引用
出版年
2024
NETL
NSTL
万方数据