非酒精性脂肪性肝病对急性缺血性卒中患者转归的影响
Impact of non-alcoholic fatty liver disease on the outcome of patients with acute ischemic stroke
俞晓蓉 1韦存胜 1陈媛 1杨婷婷 1陈雪梅1
作者信息
- 1. 南京医科大学附属江宁医院神经内科,南京 211100
- 折叠
摘要
目的 探讨非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)对急性缺血性卒中(acute ischemic stroke,AIS)患者转归的影响.方法 回顾性纳入2017年6月至2023年12月间在南京医科大学附属江宁医院就诊的AIS患者.在发病后3个月时应用改良Rankin量表评价转归,0～2分定义为转归良好,＞2分定义为转归不良.采用多变量logistic回归分析确定NAFLD对AIS患者转归的影响.结果 共纳入143例AIS患者,男性95例(66.43％),年龄(67.79±11.15)岁.96例(67.13％)转归良好,47例(32.87％)转归不良.多变量logistic回归分析显示,校正混杂因素后,NAFLD与AIS患者转归不良独立相关(优势比2.500,95％置信区间1.015～6.161;P=0.046).结论 NAFLD是AIS患者转归不良的独立危险因素.
Abstract
Objective To investigate the impact of non-alcoholic fatty liver disease(NAFLD)on the outcome of patients with acute ischemic stroke(AIS).Methods Patients with AIS visited the Affiliated Jiangning Hospital of Nanjing Medical University between June 2017 and December 2023 were included retrospectively.At 3 months after onset,the modified Rankin Scale was used to evaluate the outcome,with scores of 0-2 defined as good outcome and＞2 defined as poor outcome.Multivariate logistic regression analysis was used to determine the impact of NAFLD on the outcome of patients with AIS.Results A total of 143 patients with AIS were enrolled,including 95 males(66.43％),aged 67.79±11.15 years.Ninety six patients(67.13％)had good outcome,and 47(32.87％)had poor outcome.Multivariate logistic regression analysis showed that after adjusting for confounding factors,NAFLD was independently associated with the poor outcome in patients with AIS(odds ratio 2.500,95％confidence interval 1.015-6.161;P=0.046).Conclusion NAFLD is an independent risk factor for poor outcome in patients with AIS.
关键词
缺血性卒中/非酒精性脂肪肝/治疗结果/危险因素Key words
Ischemic stroke/Non-alcoholic fatty liver disease/Treatment outcome/Risk factors引用本文复制引用
出版年
2024
NETL
NSTL
万方数据