Neutrophil/lymphocyte ratio and triglyceride-glucose index predict no early neurological improve-ment after intravenous thrombolysis in non-diabetic patients with acute ischemic stroke
Objective To investigate the predictive value of the neutrophil/lymphocyte ratio(NLR)and triglyceride-glucose(TyG)index for no early neurological improvement(ENI)of non-diabetic patients with acute ischemic stroke(AIS)after intravenous thrombolysis.Methods Non-diabetic patients with AIS received intravenous thrombolysis in the First Affiliated Hospital of Bengbu Medical University from January 2023 to December 2023 were retrospectively included.Their demographic and baseline clinical data were collected.ENI was defined by a ≥8-point improvement in the National Institutes of Health Stroke Scale(NIHSS)or an NIHSS score of 0 or 1 at 24 hours after intravenous thrombolysis.Multivariate logistic regression analysis was used to determine the independent influencing factors of ENI in patients with AIS after intravenous thrombolysis.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of NLR and TyG index for no ENI.Results A total of 122 non-diabetic patients with AIS were enrolled,including 90 males(73.8％),aged 64.43±9.59 years,and 37(30.3％)patients achieved ENI.Multivariate logistic regression analysis showed that the baseline NIHSS score(odds ratio[OR]1.110,95％confidence interval[CI]1.007-1.224;P=0.036),NLR(OR 1.199,95％CI 1.001-1.437;P=0.001)and higher TyG index(OR 2.069,95％CI 1.009-4.244;P=0.047)were the independent predictors of no ENI.ROC curve analysis showed that the area under the curve of NLR predicting no ENI was 0.682(95％CI 0.581-0.783;P=0.001).The optimal cutoff value was 3.44,and the specificity and sensitivity were 75.7％and 57.6％,respectively.The area under the curve of TyG index for predicting no ENI was 0.648(95％CI 0.539-0.757;P=0.009).The optimal cutoff value was 8.785,and the specificity and sensitivity were 62.2％and 74.1％,respectively.Conclusion NLR and TyG index have certain predictive value for no ENI in non-diabetic patients with AIS after intravenous thrombolysis.
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