Role of dipeptidyl peptidase-4 inhibitors in the prevention and treatment of ischemic stroke
Diabetes is an important risk factor for ischemic stroke,and stress hyperglycemia after ischemic stroke will aggravate ischemic brain damage.Dipeptidyl peptidase-4(DPP-4)inhibitors,as newly developed hypoglycemic drugs in recent years,have become one of the important research directions of type 2 diabetes drugs.Although the existing clinical trial data have not clearly confirmed the effectiveness of DPP-4 inhibitors in preventing ischemic stroke in patients with diabetes,animal model studies have shown that DPP-4 inhibitors can exert protective effects during ischemic brain injury through mechanisms such as anti-inflammatory,anti-apoptotic and promoting neurogenesis and angiogenesis.This article reviews the role and possible mechanisms of DPP-4 inhibitors in the prevention and treatment of ischemic stroke.
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