Associations of serum low-density lipoprotein cholesterol with hematoma enlargement,early neuro-logical deterioration,and outcome in patients with acute spontaneous intracerebral hemorrhage
Objective To investigate associations of serum low-density lipoprotein cholesterol(LDL-C)with hematoma enlargement,early neurological deterioration(END),and outcome in patients with acute spontaneous intracerebral hemorrhage(ICH).Methods"A multi-center registration study for spontaneous intracerebral hemorrhage in Inner Mongolia"(registration number:ChiCTR2000029494)database was used to include patients with ICH who completed their first head CT scan within 6 hours after onset,underwent blood lipid examination,CT follow-up within 24 hours of onset,and accurately measured hematoma volume using 3D Slicer software between June 2020 and September 2022.HE was defined as hematoma volume increasing＞33％or＞6 ml at 24 hours,or ventricular hematoma volume increasing≥1 ml compared to the baseline.END was defined as an increase of ≥4 in the National Institutes of Health Stroke Scale(NIHSS)score from the baseline or death within 24 hours after onset.The follow-up was conducted at 3 months after onset,and the modified Rankin Scale score＞2 was defined as poor outcome.Multivariate logistic analysis was used to determine the independent correlation between LDL-C and HE,END,and outcome.Results A total of 338 patients with ICH were enrolled,including 206 males(60.9％).LDL-C was 2.39±1.22 mmol/L.Eighty-eight patients(26.0％)developed HE,67(19.8％)developed END,and 162(47.9％)had poor outcome at 3 months.Multivariate logistic analysis showed that after adjusting for confounding factors,there was a significant independent negative correlation between LDL-C and HE(odds ratio 0.312,95％confidence interval 0.208-0.467;P＜0.001)and END(odds ratio 0.408,95％confidence interval 0.275-0.606;P＜0.001),but not with the outcome at 3 months.Conclusion Lower LDL-C is associated with HE and END in patients with ICH,but not with the outcome.
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