Oral microbiota is the second largest microbiota in the human body.Due to its unique ecological environment,oral microbiota can affect oral health and whole body condition in various ways.With the progress of research,the role of oral microbiota in cardiocerebrovascular diseases is gradually being understood.At present,it is believed that oral microbiota can affect ischemic stroke through microbiota transfer,metabolites production,systemic inflammation,and other mechanisms.This article reviews the correlation and possible mechanisms between oral microbiota and ischemic stroke.