Human Papillomavirus Infection and Cervical Cytology among Women in Guangzhou
Objective To analyze the results of human papillomavirus(HPV)infection and cervical cytology test(CCT)in outpatients,and to provide scientific basis for the prevention of cervical cancer.Methods We retrospective-ly analyzed the HPV infection rate and CCT outcomes in gynecological outpatients of a tertiary hospital in Guang-zhou from July to December 2022.Results A total of 3 573 women outpatients were included in the analysis.The to-tal infection rate of HPV was 21.66％(774/3 573),the infection rate of high-risk genotype(16 types of HPV)was 18.58％(664/3 573),and the infection rate of low-risk HPV(6 types of HPV)was 5.46％(195/3 573).Most pa-tients infected by one subtype of HPV,and the five high-risk genotypes with the highest infection rate were HPV52,16,39,58,51,and the highest low-risk genotype was HPV81.The total infection rate of HPV,high-risk gene infec-tion rate and low-risk gene infection rate in different age groups showed U-shaped distribution,and the differences were statistically significant(P＜0.001).14.05％woman were CCT positive,of whom 10.13％,3.44％,and 0.48％had atypical squamous cells,low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial le-sions,respectively.The HPV infection rate,high-risk gene infection rate and low-risk gene infection rate in women with abnormal cytology were higher than those in women with normal cytology,and the differences were statistically significant(P＜0.001).Conclusion The most common subtypes of HPV infection are HPV52,16,39,58,51.Cervical cytological lesions are related to HPV infection.Appropriate cervical cancer prevention strategies should be developed according to the HPV infection rate and infection type of women at different ages.
Human papillomavirusGenotypeCervical cancerHPV vaccine
NETL
NSTL
万方数据
