Analysis of the Dose-response Relationship Between Body Mass Index and the Strength of Association with Dyslipidemia among Community Residents of Wuhan
Objective To assess ongoing BMI trends in Wuhan residents and analyze the BMI-dyslipidemia dose-response relationship,aiming to provide scientific evidence for dyslipidemia prevention and control in the re-gion.Methods A multi-stage stratified sampling method was used to select permanent residents aged 18 years and above in Jiang'an District,Wuhan.The questionnaire survey,physical measurements,and laboratory tests were con-ducted among them in 2022.Non-conditional Logistic regression and Restricted cubic splines were employed to ana-lyze the association and dose-response relationship between BMI and the occurrence of Dyslipidemia.Results Ulti-mately,a total of 3 173 participants were included.The prevalence of overweight and obesity among residents in the Jiang'an District of Wuhan were 31.30％and 8.95％,respectively.The standardized prevalence rates of dyslipi-demia,high total cholesterol(TC),hypertriglyceridemia(TG),elevated low-density lipoprotein cholesterol(LDL-C),and low high-density lipoprotein cholesterol(HDL-C)were 20.49％,2.60％,9.78％,3.17％,and 6.08％,respective-ly.Both overweight(OR=1.118,95％CI:1.083-1.154)and obesity(OR=1.181,95％CI:1.123-1.243)were signifi-cantly associated with the occurrence of Dyslipidemia.The BMI of male(x2=6.67,P＜0.05),female(x2=6.07,P＜0.05),18-＜45 age group(x2=13.40,P＜0.05),and 45-＜65 age group(x2=8.02,P＜0.05)had shown a non-linear dose-response relationship with the prevalence of dyslipidemia,while the 65 and above age group(x2=0.18,P＞0.05)exhibited a linear dose-response relationship.With the increasing of BMI,the risk of dyslipidemia gradually rose,reaching a plateau thereafter.Conclusion There is a positive dose-response relationship between continuous changes in BMI and the risk of Dyslipidemia.The prevention and control of Dyslipidemia need to shift the focus to the younger population.It is important to prioritize blood lipid control in middle-aged and young adults,and imple-ment measures such as advocating weight reduction,early prevention,and control to reduce the risk of developing re-lated chronic diseases caused by abnormal blood lipid levels.
万方数据
