目的 对2016-2022年我国围产期抑郁症患病率进行Meta分析，为我国围产期抑郁筛查时机和重点地区的确定提供依据。方法 检索CNKI、PubMed、Web of Science和Cochrane数据库，检索时限为2016年1月-2022年11月，应用Stata 16。0软件进行Meta分析。结果 共纳入29篇文献，样本总量为72 762人。Meta分析结果显示，2016-2022年我国围产期抑郁症的总患病率为25％[95％CI(0。18～0。32)]，中重度抑郁症的总患病率为12％[95％CI(0。10～0。15)]。亚组分析显示，我国围产期抑郁症的患病率孕期[29％，95％CI(0。25～0。34)]高于产后[17％，95％CI(0。09～0。26)，P＜0。05]，东部地区[25％，95％CI(0。17～0。33)]和东北部地区[30％，95％CI(0。18～0。41)]均高于中部地区[11％，95％CI(0～0。28)，P=0。20];中重度抑郁症的患病率孕期[10％，95％CI(0。06～0。14)]低于产后[15％，95％CI(0。10～0。20)，P=0。11]，东部地区[14％，95％CI(0。09～0。18)]和西部地区[13％，95％CI(0。09～0。18)]均高于中部地区[8％，95％CI(0。07～0。10)，P＜0。05]。结论 我国围产期抑郁症的患病率较高，建议在孕期和产后分别对孕产妇实施围产期抑郁筛查，并对东部地区进行重点筛查。
Meta-analysis of the Prevalence of Perinatal Depression in China from 2016 to 2022
Objective This study conducted a meta-analysis of the prevalence of perinatal depression symptoms from 2016 to 2022 in order to provide a basis for determining the screening time and key areas for perinatal depres-sion in China.Methods CNKI,PubMed,Web of Science and Cochrane databases were searched from January 2016 to November 2022 for potentially relevant articles.Meta-analysis was performed by using Stata 16.0 soft-ware.Results A total of 29 literatures were included,the total sample size was 72 762.The results of meta-analysis showed that the total prevalence of perinatal depressive symptoms in China during 2016-2022 was 25％[95％CI(0.18-0.32)],and the prevalence of moderate and severe depressive symptoms was 12％[95％CI(0.10-0.15)].Sub-group analysis showed that the prevalence of perinatal depressive symptoms in China was 29％during pregnancy[95％CI(0.25-0.34)]compared with 17％after delivery[95％CI(0.09-0.26),P＜0.05].The prevalence of the eastern region 25％[95％CI(0.17-0.33)]and the northeastern region 30％[95％CI(0.18-0.41)]were higher than that of the central region 11％[95％CI(0-0.28),P=0.20].The prevalence of moderate to severe depressive symp-toms was 10％during pregnancy[95％CI(0.06-0.14)]and 15％after delivery[95％CI(0.10-0.20),P=0.11].The prevalence in the eastern region 14％[95％CI(0.09-0.18)]and the western region 13％[95％CI(0.09-0.18)]were higher than that in the central region 8％[95％CI(0.07-0.10),P＜0.05].Conclusion The prevalence of perinatal depressive symptoms is high in China.It is recommended to carry out perinatal depression screening during pregna-ncy and postpartum respectively,and focus on screening in eastern China.
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