红细胞和血小板在血液中广泛存在，易于从血液中分离，且性质相对稳定，是一种理想的药物递送载体。近年来，大量研究利用红细胞和血小板递送抗肿瘤药物以实现高效的药物递送，其在优化药物体内行为、增加疗效以及减少给药剂量方面表现出了优异的效果。此外，其细胞膜可用作包膜材料以改善纳米药物递送系统的性质，实现仿生功能的同时减少纳米粒的毒副作用。介绍了红细胞和血小板及其膜材料的特性和制备方法，以及其在抗肿瘤药物递送中的研究进展。 Red blood cells and platelets are widely present in the blood. They are easily isolated from the blood and relatively stable in nature, making them an ideal drug delivery vehicle. In recent years, a large number of studies have been conducted to use red blood cells and platelets to deliver antitumor drugs and achieve efficient drug delivery. Red blood cells and platelets have shown excellent results in optimizing the in vivo behavior of drugs, increasing efficacy, and reducing the dose administered. In addition, its cell membrane can be used as a coating material to improve the properties of nanodrug delivery systems and achieve biomimetic functions while reducing the toxic side effects of nanoparticles. The characteristics and preparation methods of red blood cells and platelets and their membrane materials were introduced, and their diagnostic and therapeutic applications in antitumor drug delivery was looked forward.
Advanced in red blood cells and platelets as carriers for anti-tumor drug delivery
Red blood cells and platelets are widely present in the blood. They are easily isolated from the blood and relatively stable in nature, making them an ideal drug delivery vehicle. In recent years, a large number of studies have been conducted to use red blood cells and platelets to deliver antitumor drugs and achieve efficient drug delivery. Red blood cells and platelets have shown excellent results in optimizing the in vivo behavior of drugs, increasing efficacy, and reducing the dose administered. In addition, its cell membrane can be used as a coating material to improve the properties of nanodrug delivery systems and achieve biomimetic functions while reducing the toxic side effects of nanoparticles. The characteristics and preparation methods of red blood cells and platelets and their membrane materials were introduced, and their diagnostic and therapeutic applications in antitumor drug delivery was looked forward.
Red blood cellsPlateletsDrug delivery systemsTumor therapy
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