Research progress in neutrophil-mediated delivery systems
金丽敏 1吕丰 1董霞1
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作者信息
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
折叠
摘要
细胞外囊泡是一种来源于内体和细胞膜的多样化的膜性囊泡，在细胞间通讯中发挥关键作用。严格的生物发生途径赋予细胞外囊泡广泛的来源和特殊的亲本特性，复杂的内容物及表面蛋白有利于受体细胞的识别。细胞外囊泡依靠天然的生物相容性和囊泡结构来容纳更多的功能生物分子，是一种极具潜力的药物递送载体。主要介绍了细胞外囊泡的分类及生物学功能、在不同类型药物递送中的特点，讨论了细胞外囊泡在疾病治疗中的应用以及细胞外囊泡递送系统的临床转化和挑战。 Extracellular vesicles are recognized as a kind of membranous vesicle derived from endosomes and cell membranes that play important roles in intercellular communication. Strict biogenesis pathways dictate that extracellular vesicles have a wide range of origins and specific parental characteristics, while complex contents and surface proteins facilitate their recognition by receptor cells. Extracellular vesicles are considered a promising drug delivery system due to their natural biocompatibility and vesicle structure, where more functional biomolecules can be accommodated. The classification, biological functions, and characteristics of extracellular vesicles in different types of drug delivery were introduced. The application of extracellular vesicles in disease therapy and the clinical transformation and challenges of the extracellular vesicle delivery system were discussed.
Abstract
Extracellular vesicles are recognized as a kind of membranous vesicle derived from endosomes and cell membranes that play important roles in intercellular communication. Strict biogenesis pathways dictate that extracellular vesicles have a wide range of origins and specific parental characteristics, while complex contents and surface proteins facilitate their recognition by receptor cells. Extracellular vesicles are considered a promising drug delivery system due to their natural biocompatibility and vesicle structure, where more functional biomolecules can be accommodated. The classification, biological functions, and characteristics of extracellular vesicles in different types of drug delivery were introduced. The application of extracellular vesicles in disease therapy and the clinical transformation and challenges of the extracellular vesicle delivery system were discussed.
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