Research progress on immune checkpoint inhibitors for the treatment of adverse reactions related to gastric cancer
陈亚文 1高云鹤 1乔治1
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 中国人民解放军总医院第一医学中心普通外科医学部，北京 100853
折叠
摘要
传统化疗是胃癌综合治疗的基石，但复发率和转移率较高，总体预后不甚理想。免疫检查点抑制剂(ICI)的兴起为胃癌患者带来了新的曙光，并改变了当前胃癌综合治疗的格局。随着ICI的使用增加，免疫相关不良反应(irAEs)，如皮肤毒性、胃肠道毒性等也愈发常见。科学认识、早期诊断、分级管理是目前处理irAEs的主要策略。本文将就ICI治疗胃癌后irAEs的发生机制、临床表现以及如何对irAEs进行预测、治疗和管理进行综述，以期提高临床医师对irAEs的认识，更好地管理免疫治疗相关不良反应，从而改善患者的预后和生活质量。 Traditional chemotherapy is the cornerstone of comprehensive treatment for gastric cancer, but its recurrence and metastasis rates are high, and the overall prognosis is not ideal. The rise of immune checkpoint inhibitors (ICI) has brought new hope to gastric cancer patients and changed the current pattern of comprehensive treatment for gastric cancer. With the increasing use of ICI, immune related adverse reactions (irAEs) such as skin toxicity and gastrointestinal toxicity are becoming increasingly common. Scientific understanding, early diagnosis, and graded management are currently the main strategies for handling irAEs. This article aims to review the mechanisms, clinical manifestations, and prediction, treatment, and management of irAEs after ICI treatment of gastric cancer, in order to enhance the understanding of irAEs among clinical physicians, better manage immunotherapy related adverse reactions, and improve the prognosis and quality of life of patients.
Abstract
Traditional chemotherapy is the cornerstone of comprehensive treatment for gastric cancer, but its recurrence and metastasis rates are high, and the overall prognosis is not ideal. The rise of immune checkpoint inhibitors (ICI) has brought new hope to gastric cancer patients and changed the current pattern of comprehensive treatment for gastric cancer. With the increasing use of ICI, immune related adverse reactions (irAEs) such as skin toxicity and gastrointestinal toxicity are becoming increasingly common. Scientific understanding, early diagnosis, and graded management are currently the main strategies for handling irAEs. This article aims to review the mechanisms, clinical manifestations, and prediction, treatment, and management of irAEs after ICI treatment of gastric cancer, in order to enhance the understanding of irAEs among clinical physicians, better manage immunotherapy related adverse reactions, and improve the prognosis and quality of life of patients.
关键词
胃肿瘤/抗肿瘤联合化疗方案/免疫抑制剂/药物相关性副作用和不良反应
Key words
Stomach neoplasms/Antineoplastic combined chemotherapy protocols/Immunosuppressive agents/Drug-related side effects and adverse reactions
万方数据