Association between ozone exposure during pregnancy and neurodevelopment in 2-year-old children:A cohort study
Objective To investigate the associations between ozone(O3)exposure during pregnancy and neurodevelopment in children at 2-year-old.Methods Based on the birth cohort established in Yuexiu Maternal and Child Health Hospital of Guangzhou since March 2017,the maximum 8-hour concentrations of O3 during pregnancy(first,second,and third trimesters)were calculated by using the inversion model based on remote sensing satellite data according to the maternal residential address.Ages and Stages Ques-tionnaire,Third Eidition(ASQ-3)was used to evaluate offsprings'neurodevelopment at 2 years old.Multiple linear regression and Logistic regression were performed to analyze the associations between ozone exposure during pregnancy and the neurodevelopmental do-mains at 2 years old.Results The medium of maximum 8-hour concentration of O3 during pregnancy was 89.88 μg/m3,and the maxi-mum value of maximum 8-hour concentration of O3 in the third trimester was 129.32 μg/m3 with an unqualified rate of 52.63%.After adjustment for confounding factors,each 10 μg/m3 increase in the maximum 8-hour O3 concentration during pregnancy was associated with a decrease in the scores of communication(β=-8.79,95%CI:-16.73--0.86),gross motor(β=-7.19,95%CI:-12.14--2.23),problem-solving(β =-7.04,95%CI:-12.52--1.56),and person-social domains(β =-8.27,95%CI:-15.46--1.07).An increase of maximum 8-hour O3 concentration in the third trimester was associated with a decrease in the scores of prob-lem-solving domain(β=-1.76,95%CI:-3.21--0.31).The higher the maximum 8-hour concentrations of O3 during pregnancy,the higher the risks of potential developmental abnormalities in the children's gross motor and problem-solving domains,and the adjusted OR(95%CI)were 4.92(1.29,20.72)and 4.33(1.10,18.76),respectively.Conclusion Prenatal O3 exposure during pregnan-cy was associated with decreased scores of communication,gross motor,problem-solving,and person-social domains of ASQ-3 in 2-year-old children,and might also increase the risk of potential abnormal development of gross motor and problem-solving domains in 2-year-old children.
ozoneprenatal exposurechildrenneuropsychological developmentcohort study
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