孕期空气质量指数与小于胎龄儿风险之间的关联研究
Association between air quality index during pregnancy and small for gestational age
麦麦提敏江·吾拉音 1王怀林 1陈欣 1朱钲宏 1张小鑫 2龙丹 1王琼1
作者信息
- 1. 中山大学公共卫生学院,广州 510080
- 2. 杭州市疾病预防控制中心
- 折叠
摘要
目的 探讨母亲孕期空气质量指数与子代小于胎龄儿风险的关联.方法 2017 至 2020 年在广州市某医院开展前瞻性出生队列研究,通过调查问卷收集孕妇一般资料.由每日空气污染暴露数据计算每个孕妇孕早、中、晚期和全孕期空气质量指数(air quality index,AQI).采用多因素 Logistic回归模型分析母亲孕期空气质量指数(分别按分值和四分位数分组形式纳入模型)与小于胎龄儿之间的关联.结果 研究最终纳入 5 352 对孕妇及新生儿.在校正了潜在的混杂因素后,孕中期平均 AQI分值与小于胎龄儿呈现负相关.孕早期高水平 AQI(Q4 vs.Q1)与小于胎龄儿发生风险增加有关,比值比(odds rati-o,OR)及 95%的置信区间(confidence interval,CI)为 1.441(1.012,2.056).结论 孕早期高水平空气污染暴露可能影响胎儿宫内生长.
Abstract
Objective To examine the association between air quality index during pregnancy and small for gestational age.Methods A prospective birth cohort study was conducted in a hospital in Guangzhou from 2017 to 2020.The general information of pregnant women was collected using a questionnaire.Air quality index(AQI)was calculated using daily air pollution exposure during the first,second,and third trimesters and the whole pregnancy.A logistic regression model was used to evaluate the association be-tween AQI and small for gestational age.The scores and quartiles of AQI were included in the model.Results A total of 5 352 moth-er-neonate pairs were enrolled.After adjusting for potential confounding variables,the average AQI score in the second trimester was negatively associated with small for gestational age.High AQI during the first trimester(Q4 vs.Q1)was associated with an increased risk of small for gestational age(odds ratio:1.441,95%confidence interval:1.012-2.056).Conclusion Exposure to high level of air pollution during early pregnancy may affect fetal growth.
关键词
空气质量指数/小于胎龄儿/孕期Key words
air quality index/small for gestational age/pregnancy引用本文复制引用
基金项目
国家自然科学基金(42075178)
广东省基础与应用基础研究基金(2021A1515011947)
出版年
2024
NETL
NSTL
万方数据