摘要
目的 探讨海南澄迈红树湾社区高血压候鸟人群居住时间对其炎性因子及氧化水平的影响.方法 2020年10月-2021年3月于海南澄迈红树湾社区招募高血压候鸟人群作为研究对象,按居住时间分为 ≤6个月组和＞6个月组(以下称为≤6M组和＞6M组).收集研究对象的一般人口学特征、个人生活行为方式、家族病史等情况,采集研究对象血液样本,检测血脂四项(TC、TG、HDL-C和LDL-C)、血浆炎性因子(IL-6、IL-8和TNF-α)和氧化指标(SOD和MDA)水平.采用分层分析控制年龄、性别、血压分级等混杂因素,偏相关分析居住时间与血脂、炎性因子及氧化水平的相关性,多因素Logistic回归分析血脂、炎性因子及氧化水平变化的危险因素.结果 研究共纳入147例对象,其中居住时间≤6M组78例,居住时间＞6M组69例.两组间在性别、BMI、心率、饮酒状况、规律服药情况、文化程度和血压分级等方面差异无统计学意义(P＞0.05);与居住时间≤6M组相比,居住时间＞6M组的TG、TNF-α和MDA水平均有所下降(P＜0.05);偏相关分析结果显示,居住时间与TNF-α(r=-0.280)和MDA(r=-0.227)呈负相关.多因素Logistic分析结果显示,居住时间＞6M组和血压分级是TG的影响因素,BMI是TNF-α的影响因素,BMI越高者,血浆TNF-α水平越高;吸烟情况和血压分级是MDA的影响因素,吸烟者或血压分级高者血浆MDA水平较高.结论 高血压候鸟人群在海南澄迈的居住时间越长,在一定程度上可降低其血浆TNF-α和MDA的水平.
Abstract
Objective To investigate the influence of the duration of residence on inflammation and oxidation level in the migrant population with hypertension in Chengmai Mangrove Bay Community,Hainan Province,China.Methods A total of 147 migrant indi-viduals with hypertension were recruited from Chengmai Mangrove Bay Community as subjects,and according to the duration of resi-dence,they were divided into ≤6 months group(≤6M group)and＞6 months group(＞6M group).The subjects were investigated in terms of general demographic features,individual lifestyle and behaviors,and family medical history,and blood samples were col-lected to measure the levels of four blood lipid parameters(total cholesterol[TC],triglyceride[TG],high-density lipoprotein choles-terol[HDL-C],and low-density lipoprotein cholesterol[LDL-C]),plasma inflammatory factors(interleukin-6[1L-6],interleukin-8[IL-8],and tumor necrosis factor-α[TNF-α]),and oxidative indicators(superoxide dismutase[SOD]and malondialdehyde[MDA]).The stratified analysis was used to control the confounding factors such as age,sex,and blood pressure classification;the partial correlations analysis was used to analyze the correlation of duration of residence with blood lipids,inflammatory factors,and oxi-dation levels;the multivariate logistic regression analysis was used to investigate the risk factors for changes in blood lipids,inflamma-tory factors,and oxidation levels.Results A total of 47 subjects were included,with 78 subjects in the ≤6M group and 69 subjects in the＞6M group,and there were no significant differences between the two groups in sex,body mass index(BMI),heart rate,drinking alcohol,regular medication,education level and blood pressure classification(P＞0.05).Compared with the ≤6M group,the＞6M group had significant reductions in the levels of TG,TNF-α,and MDA(P＞0.05).The partial correlations analysis showed that dura-tion of residence was negatively correlated with TNF-α(r=-0.280),and MDA(r=-0.227).The multivariate logistic regression a-nalysis showed that in the＞6M group,blood pressure classification was a risk factor for TG.BMI was a risk factor for TNF-α,and thoes had the higher the BMI had the higher the serum TNF-α level.Smoking and grade hypertension were the risk factor for MDA;and those smoked or had the higher blood pressure classification had the higher the serum MDA level.Conclusion Migrant population with hypertension living longer in Chengmai,Hainan,tends to experience a certain degree of reducing of TNF-α and MDA level.
维普
万方数据